To better understand the Thermal-Hydraulic-Mechanical (THM) response of the rock caused by the high-level radioactive waste (HLW) released heat in the Callovo-Oxfordian formation (COx) in the near-field and far-field areas, a series of coupled THM modelling is performed. This study presents a case study based on the French geological repository for HLW (Cigéo project) to better assess modelling of deep geological repositories (DGR) within the DECOVALEX-2019 framework. In this study, the proposed coupled THM model, implemented in the platform of COMSOL, is validated by comparing the modelled THM results for a point heat source in an infinite rock mass with an analytical solution. It is also validated by comparing its thermal component for the Base Case with accurate results calculated using another numerical method. To shorten the calculation time, the DGR is modelled using six cuboid blocks representing 162 HLW cells and only six central HLW cells of interest modelled in detail. This simplification is validated. This model can easily be used to model not only the near-field THM response of the rock but also the far-field THM response. The influence of the boundary conditions applied on the gallery wall, HLW cell walls, and external surfaces of the model and the influence of different vertical dimensions of the geometry are studied. The sensitivity analyses of the THM parameters of COx on the THM response at different locations are performed. The influence of using a 2-dimensional (2D) model to represent a 3-dimensional (3D) repository is also investigated.