Mobile technology has gained prominence in the development agenda of the government of Ghana. This is because mobile technology has the potential to reduce poverty by providing access to financial services like savings and money transfer to users. This research employs a participatory approach to examine local self-sustaining eco-systems, cognition, and perceptions about mobile money systems as a means of enhancing livelihoods in Ghana. The study was carried out among one hundred rural women traders, randomly selected and interviewed from the Kasena Nankana Municipality in the Upper East region of Ghana. The study results showed that 90% of the traders interviewed rely on home savings for both trade transactions and household sustenance. About 77% of the traders interviewed use mobile phones and have done so for a period between 1-5 years. The MTN mobile network (the local mobile service provider) was reported as the most commonly used communication network. Poor network connectivity remains the biggest challenge to traders, and 82% still have no idea about mobile money or its perceived risks. Almost 81% of the traders reported that they do not use a barter system in their trading. Mobile money systems are still largely unknown among rural women traders. This may be attributed to the fact that rural areas lack the necessary communication infrastructure to support efficient money transfer. Only 2% of the respondents use mobile money and their use is only limited to sending money to their wards in schools as well as receiving assistance from relatives but not for trade.