Agent class

Pathogenic disease

Experimental Evidence

Reference

Bacterial

Helicobacter pylori

Decreased susceptibility to gastric infection in IL-17 knockout mice

[68]⁶⁷⁶⁸

Mycobacterium bovis, Bacille Calmette-Guerin

Increased susceptibility to mycobacterial infection in IL-17 knockout mice

[111]111120

Mycobacterium tuberculosis

Increased susceptibility to mycobacterial infection in TLR2 deficient mice

⁷³[63]⁶³

Staphylococcus aureus

Increased susceptibility to bacterial infection in Th17-inhibited mice (influenza A)

⁷⁷[69]⁶⁹

Salmonella typhimurium

Increased susceptibility to bacterial infection in Th17-cell-depleted rhesus macques (simian immunodeficiency virus)

⁷⁸[70]⁷⁰

Viral

Herpex simplex virus-1

Delayed response to viral infection in IL-17R deficient mice

⁸³[75]⁷⁵

Parasitic

Toxoplasma gondii

Reduced inflammation to parasitic infection in IL17/ILR-deficient mice; evidence of susceptibility is inconclusive

[71, 72]^79,8071,72

Leishmania major

Decreased susceptibility to parasitic infection in IL-17 knockout mice

[78]⁸¹⁷⁸

Trypanosoma cruzi

Increased susceptibility to parasitic infection in IL-17 knockout mice

82[74]74

Fungal

Candida albicans

Increased susceptibility to fungal infection in IL-23p19-deficient and IL-17R-deficient knockout mice

[78, 79]121,12278,79

Pneumocystis carinii

Increased susceptibility to fungal infection in IL-23p19-deficient knockout mice

123[77]77