Source

Example(s)

Autologous

Fat

Biological

Collagen (Zyderm^® I, Zyderm^® II, Zyplast^®, CosmoDerm^® 1, CosmoDerm^® 2, CosmoPlast^®, Evolence^®), HA (Juvéderm^® Ultra, Juvéderm^® Ultra Plus, Restylane^®, Perlane^®)

Synthetic

Hydroxylapatite (Radiesse^®), silicone oil (Silikon^® 1000), polymethylmethacrylate microspheres (ArteFill^®/ArteSense^®), polyacrylamide hydrogel (Bio-Alcamid^®), hydroxyethyl methacrylate/ethyl methacrylate (DermaLive^®/DermaDeep^®), poly-L-lactic acid (Sculptra^®/New-Fill^®)

Duration of cosmetic benefit

Example(s)

Temporary short duration

Saline

Short duration

Bovine collagen

Reversible medium to long duration

HA

Nonreversible long duration

Hydroxylapatite, polyacrylamide hydrogel, porcine collagen

Nonreversible very long duration

Silicone oil, polymethylmethacrylate microspheres, hydroxyethyl methacrylate/ethyl methacrylate, poly-L-lactic acid

Nonreversible variable duration

Fat

Risk profile

Example(s)

Low

Saline, HA

Medium

Collagen, hydroxylapatite, polymethylmethacrylate microspheres, poly-L-lactic acid, fat

Higher

Silicone, polyacrylamide hydrogel, hydroxyethyl methacrylate/ethyl methacrylate

Level of physician skill, training, experience, and judgment

Example(s)

Low

Saline

Medium

HA, collagen

High

Hydroxylapatite, polymethylmethacrylate microspheres, poly-L-lactic acid, fat, silicone, polyacrylamide hydrogel, hydroxyethyl methacrylate/ethyl methacrylate