Category

Clinical features

Criteria

APS-1

Addison disease, Chronic candidiasis, hypoparthyroidism

At least two of the three conditionsmust be present

Associated immune diseases (alopecia, pernicious anemia, gonadal failure, chronic active hepatitis, AITD, vitiligo, type 1 diabetes mellitus)

APS-2

Addison disease, AITD, type 1 diabetes mellitus

Addison disease + this/these associated disease

Associated immune disorders

APS-3

AITD, with one of the autoimmune diseases

AITD without Addison disease/ hypoparathyroidism, associated one of organ specific autoimmune disease listed in A;B;C;D

APS-3A

Type I diabetes mellitus with/without other endocrine disease ( gonadal failure)

AITD+ Autoimmune endocrine disease

APS-3B

Gastrointestinal or hepatic autoimmune diseases (perncious anemia,inflammatory bowel disease, auitoimmune hepatitis, autoimmune gastritis, primary biliary cirrhosis)

AITD+ Autoimmune gastrohepatic disease

APS-3C

Vitiligo with/without alopecia areata and/ or myasthenia gravis, multiple sclerosis

AITD+ skin ± neuromuscular-nervous system autoimmune disease

APS-3D

Systemic and discoid lupus erythematosus, rheumatoid arthritis, seronegative arthritis, systemic sclerosis, Sjögren syndrome, Werlhof syndrome, antiphospholipid syndrome, vasculitis)

AITD+ rheumatological autoimmune disease ± hematologic disease

APS-4

Other autoimmune disease not included previous groups

Different combinations with/without non-organ spesific autoimmune disease